Monitor Closely (one)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Mitotane is a solid inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for doable dosage adjustments.
Ergotism manifested by intense arterial vasoconstriction, producing indicators and symptoms of peripheral vascular ischemia
ergotamine, bromocriptine. Possibly will increase toxicity of one other by pharmacodynamic synergism. Keep away from or Use Alternate Drug. The concomitant use of bromocriptine with ergot alkaloids may likely produce ergot toxicity; for that reason the combination needs to be averted.
There are no reports on placental transfer or teratogenicity of The mix of ergotamine and caffeine
ergotamine will improve the degree or outcome of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Coadministration of moderate CYP3A4 inhibitors with midazolam intranasal might lead to greater midazolam systemic publicity, which can lengthen sedation.
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duvelisib will increase the amount or impact of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration with duvelisib raises AUC of the delicate CYP3A4 substrate which can raise the chance of toxicities of such medications.
acetazolamide will raise the level or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
mifepristone will increase levels of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Contraindicated with CYP3A substrates which have a slim therapeutic index .
itraconazole will enhance the amount or effect of get more info ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Increased danger of ergotism leading to cerebral ischemia and/or ischemia from the extremities
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conivaptan will improve the level or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.